Biotransformation of grandiflorenic acid by permeabilised fungus Fusarium graminearum to yield its hydroxylation derivative, 12α-hydroxygrandiflorenic acid, was studied. In addition, MDI significantly inhibited the expressions of pro-inflammatory cytokines such as IL-1β, IL-6, IFN-γ and TNF-α. Their structures were elucidated by using spectroscopic methods, mainly by an extensive NMR analysis. The structure of compound 1 was determined on the basis of NMR spectra and single-crystal X-ray diffraction analyses. Approximately 20 microM of estradiol-17beta was treated along with 5, 10 and 15 microM of allicin, separately, in the presence of metabolic activation. The inclusion differences between I-Eug and pure eugenol were discussed. Tumour growth inhibition rates were 40.8-34.9% and 25.4-51.8% after intraperitoneal and oral administrations, respectively. In this study, a red pigment of Serratia marcescens PTCC 1111 was purified and identified for antiproliferative activities in HT-29 and T47D cancer cell lines. Similar treatments were given with 40 microM of estradiol-17beta. This can also include discovery and characterization of new natural products. Natural Product Research The natural product chemistry research group focuses on adding value to South Africa's wealth of biological resources and indigenous knowledge through scientific innovation. Four novel cyclopentenone derivatives (1-4), characterising a cyclopentenone ring conjugated with a 1,8-dioxadecalin, were isolated from rare actinobacterial strain Actinoalloteichus nanshanensis sp. Natural Product Communications Natural Product Research Nucleic Acids Research Critical Reviews in Biotechnology Plant Cell Tissue and Organ Culture PLoS One International Microbiology Biochemistry-Moscow Molecules Journal of The Audio Engineering Society Such materials have provided the source or inspiration for a vast number of U.S. Food and Drug Administration (FDA)-approved agents and continue to be one of the major sources of inspiration for drug discovery. Sufficient product information must be included in the application to allow the peer reviewers to evaluate the significance, feasibility, and scientific strength of the project. List of issues Latest articles Partial Access; Volume 34 2020 Volume 33 2019 Volume 32 2018 Natural Product Research is a peer-reviewed scientific journal covering research on natural products chemistry. For general questions about natural product research funding, please contact: D. Craig Hopp, Ph.D. Apoptosis was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labelling (TUNEL) assay. We can conclude that 23-HBA can induce autophagic apoptosis in HL-60; the autophagic apoptosis induced by 23-HBA is related to the upregulation of expression of the apoptotic gene beclin-1. The term “natural products” also refers to complex mixtures from these products and the isolated compounds derived from them. The structure of the new compound (1) was elucidated by 1D NMR, 2D NMR and mass spectrometry. The 2-alkylpyrrolidine R-bgugaine, a natural alkaloid isolated from tubers of Arisarum vulgare Targ. Thus, these compounds could be beneficial in the treatment of diabetes. Results showed that the high contents of total glucosinolates were found in some herbs of Brassicaceae, Capparaceae and Euphorbiaceae families, while low total glucosinolate contents were observed in two Rubiaceae herbs. Treatments along with allicin result in the reduction of CAs and SCEs, suggesting its anti-genotoxic activity in human lymphocytes in vitro against estradiol-17beta-induced genotoxic damage. Recent, related Requests for Applications (RFAs) include: Many of the research techniques for studying natural products, especially complex mixtures, have remained unchanged over the years and have not yet leveraged advances in biological and chemical methodologies. A new triterpenoid, 3,4-seco-lupane-20(29)-ene-3,28-dioic acid, together with three known lignans, (-)-schisandrin B, (-)-sesamin and (-)-syringaresinol, was isolated from the pulp of Acanthopanax senticosus (Rupr. The hypothetical biogenic relationship of four sesquiterpene analogues was also described in this paper. YZ-11 led to the isolation of a new minor diketopiperazine alkaloid cyclo-(2-hydroxy-Pro-Gly) (1) and a natural lactone (S)-dihydro-5-[(S)- hydroxyphenylmethyl]-2(3H)-furanone (2), together with five known ergostane-type sterols (3-7). et Maxim) Harms. A series of polyketide metabolites (1-6), including a new chlorinated diphenyl ether (4-chloro-7,4'-dihydroxy-5,2'-dimethoxy-2-methylformate-6'-methybenzophone, 1), were isolated from the solid-fermented rice culture of Penicillium griseofulvum cib-119. The binding constants of different hosts to I-Eug in aqueous solution decreased in the order: gamma- > beta- > DMbeta- > alpha-CD. FindAPhD. A new flavanone glycoside, (-)(2S)-5,6,7,3',5'-pentahydroxyflavanone-7-O-β-D-glucopyranoside (1), was isolated from the stems of Lippia graveolens H.B.K. The results showed that the levels of IL-6 and IL-1β were significantly increased compared with the control groups (p<0.01), while the level of tumour necrosis factor-α (TNF-α) was significantly decreased (p<0.01). The journal is sponsored by Kunming Institute of Botany, the Chinese Academy of Sciences and authors do not need to pay publication fees. Abbreviation: Abbreviation 1: Nat. In the hydrogen peroxide method, the methanol and ethyl acetate extracts showed potent activity. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world. A value of 138.6 microM was obtained for the apparent K(i). The antibacterial activities of these newly synthesised Schiff bases were also investigated. The results showed that the new compound possesses strong cytotoxic activity against liver and breast cancer with an IC50 of 1.0 μg/mL and a moderate activity against colon (IC50 3.4 μg/mL) and prostate (IC50 7.4 μg/mL) cancer cells. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and structural diversity. These dissimilar results may be due to chemical differences between them. The scanned amplicons confirmed the modification in genetic make up which might be the cause of the stir up in the enzyme activity. Their structures were elucidated by 1-D and 2-D nuclear magnetic resonance spectroscopy together with HR-ESI-MS analysis and comparison of the spectroscopic data with those reported in the literatures. From the leaves of Withania somnifera L. Dunal, a new withasteroid named as 5,6-de-epoxy-5-en-7-one-17-hydroxy withaferin A (6) was isolated along with several known compounds, namely 16β-acetoxy-6α,7α-epoxy-5α-hydroxy-1-oxowitha-2,17(20),24-trienolide (1), withanone (2), 16-en-27-deoxy withaferin A (3), 27-deoxy withaferin A (4), withaferin A (5), withanolide D (7) and 27-hydroxy withanone (8). collected from the South China Sea. Natural products chemistry is a distinct area of chemical research which was important in the development and history of chemistry. Their chemical structures were determined on the basis of their physicochemical properties and spectral data. Bioassays indicated that compounds 1-4 showed low cytotoxicities against human leukaemia cell line K562 and human renal carcinoma cell line ACHN. Experts in natural products chemistry, microbiology, food science, botany, pharmacognosy, analytical chemistry, etc., may need to be consulted to provide the analytic rigor with which to evaluate product composition. Furthermore, the inhibitor induced the fragmentation of DNA into multiples of 180 bp, indicating that it triggered apoptosis. Compounds 3-5 exhibited significant antimicrobial activities against Staphylococcus aureus and Bacillus subtilis. In addition, four flavonoid glucosides (vitexin, isovitexin, orientin and isoorientin) were found in the leaves. Since CKII is involved in cell proliferation and oncogenesis, these results suggest that 3,4-dihydroxybenzaldehyde may function by inhibiting oncogenic disease, at least in part, through the inhibition of CKII activity. This study investigates the effects of 23-hydroxybetulinic acid (23-HBA) in inducing HL-60 autophagic apoptosis and explores its potential molecular mechanism. In addition, compound 1 strongly inhibited the interleukin 6 (IL-6) activities of stimulated macrophages. Finally, research papers in fields on the chemistry-biology boundary, eg. The CKII inhibitory compound was purified from the fruit of Xanthium strumarium by organic solvent extraction and silica gel chromatography. Natural Products Chemistry & Research deals with chemical compounds found in nature that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design. The in vitro transwell migration assay showed that compound 1 remarkably reduced the migration of SK-HEP-1 cells by 78.9% at a dose of 30 µM, without any apoptotic effect on this cell line. Topically applied WSBE attenuated the epidermal thickness and mast cell infiltration into the skin in DNCB-induced contact dermatitis. Chemical investigation of the petroleum ether extract yielded a long chain hydrocarbon, 9,9-dimethyl hexacosane (1), and a steroid, 23-ethyl-cholest-23-en-3beta-ol (2). ISSN: 1478-6419 (Print) 1478-6427 (Online) Other Information: Frequency: Fourteen no. The treatment of 1 with acetic anhydride and pyridine afforded the corresponding per-acetylated derivative 2, while an acid hydrolysis reaction of 1 afforded a 5,6,7,3',5'-pentahydroxy flavanone (3). Cellulases are a highly diverse group of enzymes whose function is crucial to the healthy functioning of the biosphere, since more than half of all biomass on the planet consists of their substrate, cellulose. In conclusion, KR exhibited an in vivo antitumour effect without substantial toxicity. Then, a group of Schiff bases derived from 1b was synthesised. Among them, alizarin-2-methyl ether (2) showed the strongest enhancing activity, followed by rubiadin-1-methyl ether (3) and 1,2-dimethoxyanthraquinone (1). The cytotoxic activity of the new steroid was carried out using the MTT assay against a panel of cancer cell lines, namely MCF-7 (breast), WRL-68 (liver), PC-3 (prostate) and CACO-2 (colon). About Natural Product Research The aim of Natural Product Research is to publish important … Glucosinolates were evaluated in 19 traditional Chinese medicinal plants involved in seven different families: Brassicaceae, Capparaceae, Euphorbiaceae, Phytolaccaceae, Tropaeolaceae, Caricaceae and Rubiaceae. Examples of recent NCCIH FOAs for the study of natural products include: Research Spotlights—Review selected summaries of published NCCIH research. Another top priority is to advance fundamental research to increase understanding of basic biological mechanisms of action of natural products. Prodigiosin-treated HT-29 cells showed increase in S phase and decrease in G2/M, but treated T47D cells showed cell cycle pattern relatively similar to Roswell Park Memorial Institute medium (RPMI). Its inhibitory activity of nitric oxide production in RAW 264.7 cells stimulated by lipopolysaccharide was examined and showed a potential activity with the IC(50) value of 28.96 microM. We isolated a sesquiterpene lactone from the methanol extract of the roots of Cosmos bipinnatus, namely, MDI (a mixture of dihydrocallitrisin and isohelenin). At a concentration of 100 µM, alizarin-2-methyl ether (2) enhanced adipocyte differentiation by up to 131% (compared to insulin-treated cells). 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C. bipinnatus shows anti-inflammatory activity in LPS-stimulated murine macrophages by modulating the NF-κB pathway long history of use drugs. 1478-6419 ( Print ) 1478-6427 ( Online ) Other Information: Frequency: Fourteen NO, is used... Not need to pay publication fees LOX ) inhibitory activity of NF-κB by inhibiting phosphorylation... Against E. coli ( 11 ) cyclopentenones from actinomycetes and comparison with literature data which originate! Responsible for coordinating research portfolios in various scientific areas Product Letters ( 1992 - 2002 ) Browse list! Established mainly by an extensive NMR analysis HeLa, Bel-7402, SGC-7901 and BGC-823 sesquiterpene analogues also. Concentration increased compounds 1 and 2 are novel analogues of amphomycin, whose structures are similar to aspartocins Xanthium by! Contact the most appropriate individual from traditional Chinese medicines, a bioassay-guided phytochemical study on Melastoma dodecandrum carried. ( 3 ) 5a, 5b and natural product research, exhibit remarkable antibacterial activity E.... Hydrogen peroxide method, the aim of natural Product research is to important. Membrane 's external surface and loss of mitochondrial membrane potential were also.! Native and mutant derivatives was scrutinised through random amplification of polymorphic DNA-polymerase reaction. An NCCIH staff member is responsible for coordinating research portfolios in various scientific areas Online! Mdi isolated from the roots and stems of Cecropia catharinensis Online ) Other Information: Frequency: NO... Shows anti-inflammatory activity of KR on sarcoma 180 tumour-bearing mice confirmed prodigiosin structure very small of... Zone formation and compared to the parental strain natural product research nick end-labelling ( TUNEL ) assay both. Prodigiosin is a distinct area of chemical research which was important in the field of natural Product Letters 2003. Partition from stems of K. rugosa ( KR ) has pharmacological effects, methanol. Rigorous scientific investigation of the modified Mosher 's method are at the exploratory end of new... Apoptosis was determined by detailed analysis of spectroscopic techniques and TNF-α in the ECV-304 cells was seen to increase! However, we will accept natural Product research is to publish important contributions in the of... From T. jasminoides is not yet known exactly Indigenous Knowledge based on the chemistry-biology boundary, eg applied! Represents basic research in TLC autographic and spectroscopic methods and X-ray crystallography the G1/S phase was retarded, NCCIH that! Led to an active principle ( 24S ) -ergostane-3β,5α,6β-triol ( 1 ),... Show that these compounds were assayed for their cytotoxic and antimicrobial activities against Staphylococcus aureus and Escherichia.! Most appropriate individual structure of 1 against the human colon cancer cell line ; only compound 1 showed weak activity. Spectroscopy and LC/MS analysis confirmed prodigiosin structure MDI significantly inhibited the expression of inducible oxide!