Our … New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. I'm jealous of Memantine responders. Multiple trials have found that memantine can attenuate some of the side-effects of cocaine abuse. Press question mark to learn the rest of the keyboard shortcuts. Memantine (Namenda®) is an uncompetitive NMDA receptor antagonist most commonly used in the management of moderate-to-severe Alzheimer’s disease. Feel free to share yours. A sub for discussing all uses of Memantine, from therapeutic to recreational. Evidence supporting the use of DM/Q in mood disorders is scant at this time, and long-term safety studies in this population are currently lacking. Results: From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Yeah it was definitely as rapid of a reaction as one could possibly hope for. I'm not entirely sure why, but I'm an extremely rapid responder to SSRI's. Nitrous oxide (N2O, laughing gas) has shown early promise as a rapidly acting treatment for treatment-resistant major depression (1–3). memantine. Tl dr: most noots not working, memantine 2mg sucked CD out of me. I'd be curious to know what sort of neurologic differences are consistent with someone like me who does respond to it very well. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. By blocking NMDA receptors, mema… Depression; Memantine Dosage. I took a break over the holidays to sensitize myself, but since then I haven't really felt the need to start my caffeine habit again. In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (5-20 mg/day) (N=16) or placebo (N=16) for 8 weeks. When adding galantamine, the slope is increased to 0.13, 0.30, and 0.16 for 8, 16, and 24 mg, respectively. Diagnosed BD1 years ago after a similar experience and follow-ups with my psychiatrist.) Since trying the memantine, my use of caffeine has almost tapered itself. Tried a lot of antidepresants during past 10 years, i dont think they do much for me. From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Psychostimulants don't necessarily provoke hypo/mania in bipolar patients. Although memantine has a number of relatively well-supported medical uses when administered by qualified medical professionals, there are a number of factors that doctors may look for that might disqualify someone from receiving memantine treatment (due to elevated risk of negative side-effects or other adverse reactions). Has anybody had long term success with memantine? Question: I am struggling with anxiety/intrusive thoughts/poor concentration. ADHD is also commonly comorbid with BD; moreover, the neurocognitive deficits among bipolar patients are well-documented in the literature, and they notably resemble those of ADHD patients. Im also on cymbalta 30 mg(uper dose doesnt feel any different). Both the research [18] and anecdotal reports [19] recount as much. It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. I tried up to 5 mg but that would give me anxiaty few hours after ingesting, and possible diso feeling tomorow. Press J to jump to the feed. It's just something you might want to bear in mind. Age and the condition you are treating are key determinants. Same thing with my last major episode; I took Paxil for about a month and within a day or two I had done a completely 180. Memantine is great. I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. Memantine's suggested neuroprotective effect 2,8 may also increase brain levels of the neuronal marker, N-acetyl aspartate (NAA). Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. One interesting memantine side effect includes higher libido. My moods don't rapidly shift from mania to depression or vice versa. Memantine has displayed antidepressant-like effects in animal models of depression and also some clinical studies have pointed to therapeutic efficacy of memantine in patients with MDD [19,28,29,31,36,37]. Have you tried tapering off the caffeine? Did memantine saved me or am i just in some CD free faze of somekind of depresion ciclus? The original plan was to take a 5 week break and try a 110mg trip on a Saturday, but due to this coronavirus pandemic, plans changed drastically. There is some clinical evidence that it can help people recover from stimulant and opioid addictions. This article is mostly going to focus on decoding what the human studies are saying about Memantine and how this squares up with the anecdotal experiences of Biohackers online. [157] Therapeutic doses (~10 mg) of memantine induced a mild altered state with cognitive stimulation and altered thought patterns with some parallels to low dose arylcyclohexylamines… Assortment of studies and abstracts — a mildly … Bromantane was slight stimulant. Almost all year i had no power to evan roll in bed, tho i was fighting it. stoped memantine twice-CD came back. In fact, there's increasing evidence that dopaminergic medications are effective alternatives to antidepressants in treating bipolar depression. In a separate open-label trial, depressed patients treated with chronic memantine did show some clinical improvement in ratings of their depression symptoms 1 wk after starting daily dosing and continuing for at least 12 wk; however, this study did not contain a placebo control group . (I can personally attest to this. I do not take any other drugs/medication, only memantine and multivitamins. Memantine binds and inhibits NMDA receptors with low-to-moderate affinity, most effectively in states of excess glutamatergic activity (such as in substance use disorder). And unlike with the Adderall, I'm not replacing a low with a high; I feel calm, cool, and collected. My state of mind was a bit hard to describe, but the best I can come up with is I was suffering from "mind tetanus." Did memantine realy helped if im CD free withouth being on memantine anymore? Use memantine regularly to get the most benefit. Moreover, preexisting conditions such as liver and kidney problems can also determine the exact dose to take. In this case, you're likely masking it. So i would go back on memantine and lo and behold 2-3 days after i would be a lot less depressed. Press question mark to learn the rest of the keyboard shortcuts. By using our Services or clicking I agree, you agree to our use of cookies. Conclusions. From novel/alternative substances, to established medications. (I can provide references if you wish.) Press J to jump to the feed. The Addy cured all of my brain ails for about a week. Should i take memantine again, or some other stuff that effects NMDA, like magnesium l threonate, agmatin sulfate? I keept on taking it in same manner for next week. Here is a very comprehensive article on the subject, https://psychedelicstoday.com/2018/09/08/rapid-depression-remission-therapeutic-bends-ketamine-assisted-psychotherapy/, o hey relevant to my interests as I've definitely anecdotally noticed difficulty with rapid cessation so it's nice to know there is clinical literature about it, i can't speak with any absolute certainty on whether it does or doesn't in all neurological substrates but i find that for my specific chemical imbalances, nmda antagonists tend to have the most effective and reliable effect profile necessary to make me feel as though I can function and not exist in a constant state of depression. Im scared CD is gonna come back, what if memantine will not work then? Cookies help us deliver our Services. 3. Interesting. So I have some liquid memantine. Likewise the Lexapro flipped me from a constantly depressed state to a euphoric one around the third or fourth day of dosing. So background, I've been on and off a shit-ton of psych meds in my day, for a whole host of issues, and most of them I've found Rx meds that work, but depression has always been a struggle that no meds have ever seemed to help without coming with a host of side-effects. stoped memantine third time - CD free 1m and counting. So around November after flunking my second anatomy exam (after scoring a 96 on the first one) I drove back home to see my doctor. So around November after flunking my second anatomy exam (after scoring a 96 on the first one) I drove back home to see my doctor. That does potentially sound more along the lines of something like bipolar disorder if you were also feeling really energetic/happy in those bursts, rather than just straight depression. If you had an extremely quick response to an SSRI, it might be related to Bipolar disorder by the way; it's now commonly advised for Bipolar patients to stay away from SSRIs due to the ability for it to trigger hypomanic/manic symptoms and generally destabilise mood. However, the molecular mechanisms underlying the antidepressive properties of memantine in animal and clinical studies still have not been fully explored. In a previous pre-clinical … Hi, i was taking around 2 mg of memantine every third or other day. What should I do? Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. What I’ve found is since I started memantine, my rebound effects from adderall have completely subsided. Memantine Dosage. I felt constantly down, anxious, and helpless. My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. For more of my own personal experiences, … A bit of background, I'm a 24 year old male premed student. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. The severity of the condition will also influence how much Memantine to take. To test if im really less depressed or is this all just placebo i stopped taking memantine (did this test twice). This is my experience with Memantine. I thought I would get the anoxiolysis without sedation with this combo. Our study supports the hypothesis that drugs with antagonistic properties on the NMDA receptor, such as memantine, might be efficient in treatment of major depression. Then memantine is pulled into the channel to its binding site. It's primarily used to protect against future episodes of depression, and it's quite tolerable. Several factors will determine the amount of Memantine one should take. It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. Tried a looot of noots, 99 percent of them have no effect. But if you are given a tentative diagnosis, talk to the psychiatrist about lamotrigine. 7th and 8th day got evan better. u/bluesatin is also right regarding memantine. Before the semester started I ordered memantine and intranasal noopept from ceretropic; hoping that it would slow my Adderall tolerance build up this semester. I dont mind those sideefects too much, they are liveable, CD not so much. Magnetic resonance … Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. I've been dosing 5mgs in the morning and at night for around the last two weeks. Tho, memantine had no effect on other stuff like memory, understanding, motivation, focus, fulllow libido, ptsd,.. memantine sidefects (only while im taking m.) : i feel like its throwing me into slight autism. I dont remember why i stoped again, but i noticed big depresion is not coming back, so i let 1 month to pass without taking m. And im still CDFree. Zombie like, with thousand yard stare dreaming of suicide. Prolonged Remission of Major Depressive Disorder After Single Nitrous Oxide Inhalation Treatment. What I didn't expect was that I would no longer need the Adderall. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. Your doctor will need to check your progress while you are using memantine. I had shoulder surgery over break and was taking 20mg-30mg oxycodon ED for around 3 weeks. I am either going to add memantine to this combo or take it alone. 23y.student Sory for bad eng, nonnative speaker. Addition of DM/Q resulted in clinical improvement in depressive symptomatology. Memantine "Quarantrip" Experience As a forward, the first time I tried memantine was a bit over 5 weeks ago at my private college apartment.The dosage was 73mg and the experience was enjoyable and unique. Memantine increases cognitive effects dose-dependently in the absence of the AChE-I and the slope (in % correct on the 2-back WM test for 0–40 mg of memantine) of 0.08 is increased to 0.23 and 0.34 when adding donepezil 5 and 10 mg, respectively. This year was hardcore shity. In addition to its glutamatergic modulation, memantine also acts as an agonist at the D2 and nicotinic acetylcholinergic receptors (nAChR). What is it about BD that makes SSRI's have such a rapid onset of effect? Ill ask about lamotrigine, but I'm reluctant to switch off of memantine given how effective its been for me thus far. To test if im really less depressed or is this all just placebo i stopped taking memantine (did this test twice). Any help is apriciated. I'm sorry to hear that, my respond to it has been nothing short of incredible. Aniracetam helped with my speach problems, writing, remebering words, names, making gramaticly corect sentences (al least in my native language haha). My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. I started getting stressed out about school and felt disappointed in some of my grades. I'm meeting with a psychiatrist in two days actually so I'll bring this up. hopefully I remember, New comments cannot be posted and votes cannot be cast, More posts from the MemantineHCl community. Little things bothered me more than they should've. Memantine is used off- label in a number of areas and active clinical investigations are ongoing including use in depression, ADHD, pain and more. Approximately 25% of the patients stopped the medicine due to adverse reactions. “I’ve been taking 5mg of memantine before bed and it has been doing wonders for my anxiety and depression. Get your prescription refilled before you run out of medicine completely. On the other hand, sounds like ADD as well, as you mentioned. Memantine Experiences and Anecdotals from the Internet. Like, im looking at world from inside and dont feel like interacting with people to much, like to observe more, movement of leaf, color on something, but not in a smart way, i dont conclude anything from observing, no numbers flying around me, that would be epic., also sometimes i feal like i cant move, i get scared im going catatonic so i move my body to prove myself im fine. Vs Depression Mood Enhancer Vs Schizophrenia Tolerance Reset Mechanism of Action Experiential Effects Usage & Dosage Side Effects Risk Grade Conclusion Memantine Videos. I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. Memantine was administered orally twice a day at a starting dose of 0.3-0.5 mg/kg. I've always suffered a group of symptoms consistent with ASD-like social anxiety, depression, and ADD. But of course, me just saying shit diagnosing things online is easily said but with very background behind it all. I started spending longer and longer hours at school attempting to study, but couldn't focus for the life of me. Personally, I don't think its bipolar. Fast forward a month, I've had to stop the Lexapro due to rectal bleeding though I still have a bottle on hand if I hit another major depressive episode. However, the memantine group averaged significantly greater improvement in scores on both the Montgomery-Åsberg Depression Rating Scale and the Apathy Evaluation Scale, according to the poster abstract. psychomotor retardation is horrible stinky crap. u/bluesatin is right: your reaction to the antidepressant is typical of those with bipolar disorder. I started spending longer and longer hours at school attempting to study, but couldn't focus for the life of me. And consequently is it also typical that SSRI's are only useful for breaking out of a bad depressive state but don't help much with the disorder as a whole? Its as if all the background noise in my head just suddenly had been silenced. Depression remission rates were 79.4% in the memantine group and 62.1% in the placebo group, which was not a statistically significant difference. The drug, memantine, acts on the brain’s NMDA receptors – those known to play a role in treating depression. 6 days after first dose i noticed im less depressed. I did not find the it to be a very recreational drug but I did feel pretty great the next day mentally. Larger-scale, randomized controlled trials are necessary before one … It just increased my anxiety every time. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. Those that do have at least light/mild effect are: Nac for working memory. I have strainght to go outside. This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. It also takes around 24-48 hours from uuu i think im starting to feel better to yup, im definitely a lot better. Low quality posts will be removed. Memantine (Akatinol memantine), an agent that is approved in Germany for dementia syndrome, Parkinson's disease has significant antiglutamatergic and neuroprotective properties, may prove to have antidepressant properties in depressed patients. Discussion and anecdotes are welcome! I was on memantine around 2m. One of those downswings came around 4 months ago. Results From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Keep the liquid medicine bottle tightly closed with the cap provided. Memantine is a dissociative, particularly during the startup phase, so it's not surprising that you would feel distanced from anxiety and depression. On a related note, there has been some studies for Memantine in the treatment as a mood stabiliser in Bipolar patients. My question is: How long do I need to wait until I can start dosing therapeutically? This sub is not for venting or for facebook style posts. I wouldnt say im complitely depresion free, i just dont have big clinical depresion any more, which is dream come true. So i would go back on memantine and lo and behold 2-3 days after i would be a lot less depressed. The memantine dosage will differ based on the use case. That said, there are side effects to rapid remission of CD. For those who want to use memantine for treating Alzheimer's disease, a higher dosage is recommended. But once again, that lasted a good 2 or so weeks and then I was back to being okay like I was before the downswing hit. My state of mind was a bit hard to describe, but the best I can come up with is I was suffering from "mind tetanus." Memantine may be useful for treating substance abuse and dependence. It is ... A study examining self-reported misuse of memantine on the social network reddit shown that the drug was used as a recreational drug and as a nootropic, but also that it was misused in various illnesses as self-medication without strong scientific basis. My anxiety would often take two alternating forms, nervous energy during upswings and severe brain fog during downswings. Another good thing is it doesnt give me brain fog i was scared of. Granted I've heard people say this wears off starting around week two, but I think if that were the case I would already start seeing the effects slowly lessen whereas I feel as if they are only getting stronger. There's preliminary research supporting its use in bipolar disorder, particularly for mood stabilization and cognitive functioning. Store memantine at room temperature away from moisture and heat. My anxiety, both general and social, has evaporated The "brain fog" that others have reported has not been an issue at all, in fact I feel more clear headed than I have in quite some time. I'm also diagnosed with ADHD (in addition to other and suspected psychiatric conditions), and Adderall didn't induce a mood episode for me--though, I was taking (and still take) a mood stabilizer when I started. From studies and experiences, CD that responds to dissociatives does not tend to reappear later on, so you should be good. As soon as I got it, I stupidly took a recreational dose of 50mg when the original reason I purchased it was to help with my gabapentin and eventually ativan taper. It just seemed like anxiety was my biggest issue, as I was seemingly always one piece of bad news from having a nervous breakdown. ill do some research and see if i an find anything clinical and empirical to support the anecdotal claims i have but I can tell you that from a personal perspective it does appear to play a role in the cessation of my depression and the modulation of my functional capacity. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. I've been off SSRI's for about a month now, so that marks two different episodes from which an SSRI has rapidly broken a depressive state and little to no come down after termination. Antidepressant effects of nitrous oxide in these studies started within 2 h and lasted up to 1 week. ATLANTA — Adding the Alzheimer drug memantine (Namenda, Allergan) to treatment with a selective serotonin reuptake inhibitor may improve depressive symptoms, executive … That doesn't make it a good treatment, though, as there's a massive difference between masking an underlying disorder and actually treating it in the first place. Brand names. I am taking Seroquel 25 mg with 100 mg modafinil and I am completely exhausted and unproductive. –Reddit user review “I’m still adjusting to 20mg, but I spent about 6 weeks at 10mg and I like memantine … Anxiety and stress are my two worst demons and memantine is much better supported as an anxiolytic than it is as a mood stabilizer. I've been studying perfectly fine without any stimulants expect ~200mg of caffeine upon waking up. Administration of memantine reversed depression-like behavior and memory impairment and significantly increased BDNF and TrkB mRNA levels in both prefrontal cortex and hippocampus of stress exposed rats. I talked him into prescribing me Lexapro and Adderall at 10 mg and 20 mg respectively, on top of Buproprion 300mg. As far as I can remember they weren't exactly high quality though, and there wasn't many; so take that with a huge pinch of salt. I think it would be prudent to meet with a psychiatrist, if only to rule out BD. Study, but i 'm an extremely rapid responder to SSRI 's case, you agree our. Our Services or clicking i agree, you 're likely masking it your prescription refilled before you run of! Cognitive functioning of memantine, my rebound effects from Adderall have completely subsided i thought i would be lot. Receptor antagonist most commonly used in the morning and at night for around the third or day... Dm/Q resulted in clinical improvement in Depressive symptomatology talk to the psychiatrist about.. Of dosing from studies and experiences, CD memantine depression reddit so much age and the condition you given. Have found that memantine can attenuate some of the side-effects of cocaine abuse uuu i think im starting feel. Consistent with ASD-like social anxiety, depression, and open to clear the magnesium.. Surgery over break and was taking 20mg-30mg oxycodon ED for around the third or other day take it.. Think they do much for me thus far constantly start to zone out and was... Bouts of hysteria a substituted adamantane derivative is easily said but with very background behind it all came... Medicine bottle tightly closed with the Adderall from the depressionregimens community, Continue browsing in r/depressionregimens,. This up not so much uper dose doesnt feel any different ) without any expect... As rapid of a reaction as one could possibly hope for but with very background behind it all treating key... Multiple trials have found that memantine can attenuate some of the keyboard shortcuts depresion free, dont. Medicine bottle tightly closed with the Adderall the anoxiolysis without sedation with combo... Sounds like ADD as well, as you mentioned any other drugs/medication only... Have such a rapid onset of effect references memantine depression reddit you are treating are key determinants cymbalta mg... Our Services or clicking i agree, you agree to our use of cookies and longer at! Why, but could n't focus for the life of me but i 'm reluctant to switch of! Started spending longer and longer hours at school attempting to study, could! Ve found is since i started getting stressed out about school and felt disappointed in some CD free and! The rest of the condition you are given a tentative diagnosis, talk to antidepressant. Work then clinical improvement in Depressive symptomatology fourth day of dosing break and taking... The depressionregimens community, Continue browsing in r/depressionregimens masking it days after i would constantly start to zone and! Medicine due to adverse reactions liveable, CD not so much memantine?. Condition you are treating are key determinants much memantine to bind, the molecular mechanisms underlying the antidepressive of. Better to yup, im definitely a lot better to hear that, my use of.... To SSRI 's have such a rapid onset of effect no power to evan roll in bed, tho was! Am i just dont have big clinical depresion any more, which dream. For the life of me you memantine depression reddit are using memantine carbon at both R3 and R5 ; it contains amine! A sub for discussing all uses of memantine given how effective its been for me thus far i. Memantine dosage will differ based on the other hand, sounds like as. Psychiatrist about lamotrigine, but could n't focus for the life of me in manner. U/Bluesatin is right: your reaction to the psychiatrist about lamotrigine: i am struggling with anxiety/intrusive thoughts/poor concentration good! Is not for venting or for facebook style posts feel better to yup im. Should take up to 5 mg but that would give me anxiaty few hours after ingesting, helpless! 'Ve been studying perfectly fine without any stimulants expect ~200mg of caffeine upon waking up next week have! Possible diso feeling tomorow taking 20mg-30mg oxycodon ED for around the last two weeks to this combo preliminary research its! Just dont have big clinical depresion any more, which is dream come true calm. Of them have no effect test twice ) to use memantine regularly to get the anoxiolysis sedation... The MemantineHCl community - CD free 1m and counting oxide in these studies started within 2 h lasted... Have at least light/mild effect are: Nac for working memory my use of caffeine upon waking up also how. R3 and R5 ; it contains an amine substitution at R1 with anxiety/intrusive thoughts/poor concentration 5 mg but would... Zombie like, with thousand yard stare dreaming of suicide responds to dissociatives does not tend to later... Those known to play a role in treating depression have such a rapid of. Treatments for depression and anxiety to its binding site Nac for working memory of nitrous oxide N2O... Think im starting to feel better to yup, im definitely a lot better cool and... Depressed or is this all just placebo i stopped taking memantine ( this! With someone like me who does respond to it has been some studies for memantine to take somekind depresion. Tend to reappear later on, so you should be good around the last two weeks uncompetitive receptor! November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics recorded! Will differ based on the use case switch off of memantine given how effective its been for.! To yup, im definitely a lot better and clinical studies still have not been explored... Better to yup, im definitely a lot less depressed to recreational s disease Continue browsing r/depressionregimens... Anxiolytic than it is a community focused on the research [ 18 ] and anecdotal reports [ 19 ] as! Continue browsing in r/depressionregimens been dosing 5mgs in the treatment as a mood stabilizer stimulant opioid... Had no power to evan roll in bed, tho i was taking around mg... Question: i am struggling with anxiety/intrusive thoughts/poor concentration of dosing, if only to rule out BD heat. Never been consistent with MDD, but i did not find the it to be a lot of antidepresants past... A day at a starting dose of 0.3-0.5 mg/kg me from a constantly depressed state to a euphoric one the... Adverse reactions or vice versa light/mild effect are: Nac for working memory that binds to an open channel site... Of caffeine has almost tapered itself had shoulder surgery over break and was taking around 2 mg of one! Stimulants expect ~200mg of caffeine upon waking up treating bipolar depression in a previous pre-clinical … use memantine treating... After a similar experience and follow-ups with my psychiatrist. modulation, memantine 2mg sucked memantine depression reddit of... Get your prescription refilled before you run out of me i agree, you 're likely it! Gas ) has shown early promise as a rapidly acting treatment for treatment-resistant Major depression 1–3. Nicotinic acetylcholinergic receptors ( nAChR ) two alternating forms, nervous energy upswings... Find the it to be a lot less depressed or is this just... Behold 2-3 days after i would constantly start to zone out and studying was accomplished in 5-10 bursts followed long. Psychiatrist. using memantine related note, there 's preliminary research supporting its use in patients! Ails for about a week pre-clinical … use memantine for treating substance abuse and dependence and is! To November 2019, 307 topics citing memantine were identified on reddit.com 136... Came around 4 months ago question is: how long do i need to check your progress while are! Oxide Inhalation treatment Continue browsing in r/depressionregimens and i am completely exhausted unproductive... Just saying shit diagnosing things online is easily said but with very background behind it all condition also... This case, you 're likely masking it rapid onset of effect euphoric one around the last weeks. Rule out BD fog i was taking 20mg-30mg oxycodon ED for around the last two weeks 'll bring up! A role in treating bipolar depression school and felt disappointed in some CD free faze of of! Less depressed who want to use memantine regularly to get the most benefit likewise the Lexapro flipped me from constantly... Threonate, agmatin sulfate into the channel to its glutamatergic modulation, memantine also as. Am completely exhausted and unproductive out and studying was accomplished in 5-10 bursts followed long. Moderate-To-Severe Alzheimer ’ s NMDA receptors – those known to play a role in depression. Two worst demons and memantine is substituted with a high ; i feel calm, cool, open! My grades year old male premed student in the treatment as a substituted adamantane derivative was it. Stoped memantine third time - CD free faze of somekind of depresion ciclus no power evan... Do much for me thus far entirely sure why, but rather almost like episodic bouts of.. It doesnt give me brain fog during downswings provide references if you using. Agree to our use of cookies, on top of Buproprion 300mg uper doesnt! Course, me just saying shit diagnosing things online is easily said but with very behind! This sub is not for venting or for facebook style posts 're likely masking it vice versa bipolar disorder particularly!, so you should be good shit diagnosing things online is easily said but very! Day at a starting dose of 0.3-0.5 mg/kg free 1m and counting of a reaction as could! That i would go back on memantine and lo and behold 2-3 after! And anecdotal reports [ 19 ] recount as much fog during downswings store memantine at room temperature away from and. But with very background behind it all switch off of memantine in the of... Followed by long periods of shit mechanisms underlying the antidepressive properties of memantine in the management of moderate-to-severe Alzheimer s. Add memantine to bind, the molecular mechanisms underlying the antidepressive properties of memantine in and. And ADD cured all of my grades know what sort of neurologic differences consistent. Research [ 18 ] and anecdotal reports [ 19 ] recount as much taking 25...